Clomiphene

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Clomiphene

DIN 01008574
50 mg
50 tablets, Square container

Systematic name: (E,Z)-2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethyl-ethanamine

Availability: In stock

$0.00
Pharmacokinetic data

Drug Class: Ovulatory stimulants                                             

Route: Oral

Effective Dose Men, steroid post cycle, 50-100 mg

Effective Dose: Women, 50 mg

Frequency: Daily

Half-Life: 5-7 Days

Detection Time: Debatable

Excretion: Urine

Side Effects

Acne: Rare

Fluid retention: Yes

Hypertension: Possible, rare

Hepatotoxicity: Can be on a long period

Aromatization: None

DHT Conversion: None

Decrease HPTA Function: None

Identifiers

CAS number : 911-45-5 
PubChem CID: 2800

ChemSpider ID: 2698

Chemical data

Formula: C26H28CINO
Mol. mass: 598.10

Melting point: 116.5-118°C

 

DESCRIPTION
Clomiphene, is a non-steroidal fertility medicine. It causes the pituitary gland to release
hormones needed to stimulate ovulation (the release of an egg from the ovary). Clomiphene
is used to provoke ovulation in women with certain medical conditions (such as polycystic
ovary syndrome) that prevent naturally occurring ovulation.
In bodybuilding, Clomiphene is used mainly off-cycle to restore normal testosterone levels.


COMPOSITION
Each tablet contains:
Medicinal ingredients. Clomiphene citrate, 50 mg.
Non-medicinal ingredients: Microcrystalline cellulose, calcium carbonate,
steric acid, magnesium stearate.


CLINICAL PHARMACOLOGY
Clomiphene inhibits estrogen receptors in the hypothalamus, which restrain negative
feedback of estrogen on gonadotropin release, leading to up-regulation of the hypothalamic–
pituitary–gonadal axis. Zuclomifene, a more active isomer, stays bound for longer periods
of time.


INDICATIONS
Clomiphene is useful in those who are infertile due to anovulation or oligoovulation. It has also
been used with other assisted reproductive technology to increase success rates of these
other modalities.


CONTRAINDICATIONS
Clomiphene is contraindicated in patients with a known hypersensitivity or allergy to
clomiphene citrate or to any of its ingredients. Clomiphene is also contraindicated for
pregnant women and patients with history of liver problems.


ADVERSE REACTIONS
The most common side effects of clomiphene are stomach discomfort, breast discomfort,
blurred vision, nausea, and vomiting. Other side effects include abnormal heart beats, acne,
allergic reactions, headaches, uterine bleeding, back pain, and muscle pain.
The most common adverse drug reaction associated with the use of clomiphene (>10% of
people) is reversible ovarian enlargement. Less common effects (1-10% of people) include
visual symptoms (blurred vision, double vision, floaters, eye sensitivity to light, scotomata),
headaches, vasomotor flushes (or hot flashes), abnormal uterine bleeding and/or abdominal
discomfort. Rare adverse events (<1% of people) include: high blood level of triglycerides,
liver inflammation, reversible baldness and/or ovarian hyperstimulation syndrome.


KNOWN SYMPTOMS OF OVERDOSAGE AND TREATMENT
Overdosage symptoms include nausea, vomiting, vasomotor flushes, visual blurring, spots or
flashes, scotomata, ovarian enlargement with pelvic or abdominal pain. In the event of
overdose, appropriate supportive measures should be employed in addition to gastrointestinal
decontamination.


STORAGE INSTRUCTIONS
Store clomiphene at room temperature, between 15-30 degrees Celsius (59° to 86° F),
in a tightly closed, light-resistant container. Keep out of reach of children.

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